Theresa May is to challenge society over differences in how public services treat people of different races.
On Tuesday, Mrs May will say the government and institutions must "explain or change" the differences.
An "unprecedented" audit pulls together data on how people of all ethnicities are treated in areas including health, education, and criminal justice.
The Equality and Human Rights Commission called for a "coherent race equality strategy" from government.
The prime minister will launch a website later containing the data, compiled from across the UK government.
"People who have lived with discrimination don't need a government audit to make them aware of the scale of the challenge," Mrs May will say.
"But this audit means that for society as a whole - for government, for our public services - there is nowhere to hide.
David Isaac, chairman of the Equality and Human Rights Commission, said the data must be used "to set the foundations for real change" and address the "entrenched inequality" revealed by the audit.
Simon Woolley, director of Operation Black Vote, praised Mrs May's "desire to grapple with the scourge of racism", adding: "unless these things are laid bare we can't begin to resolve them."
Although the audit will not focus on government policies, Mrs May will launch a number of measures to combat the differences discovered.
Under the plans, 20 hotspots for the Department for Work and Pensions will be highlighted to help people from ethnic minorities get jobs.
Measures could include mentoring schemes, traineeships for 16-24 year-olds, and offering English and Maths qualifications alongside vocational training.
The Ministry of Justice will also adopt recommendations from the Lammy Review including making prisons have performance indicators to assess how prisoners are treated.
It will also be made to publish all criminal justice data held on ethnicity and improve the recruitment, retention and progress of ethnic minority staff.
A review of pupil exclusion in schools will be announced with a focus on those most likely to be affected.