The Duke of Cambridge was visiting Liverpool’s Aintree University Hospital when he opened up about the two-year-old.
Speaking to 55-year-old patient Pagan Tordengrav, Wills revealed he thinks his little girl will be “trouble” when she grows up.
His comment may come as a surprise to some considering the little Princess always looks so angelic in photographs.
He then spoke about Prince George’s first day at school, commenting that it seems to be a far more emotional experience for mums and dads than their offspring.
"Most of the parents are in floods of tears and the children are absolutely fine,” he said.