The landmark album will boast a second disc with almost two-dozen hits from down the years, stretching back to 1983.
The 100th edition is set for release on 20 July, with the likes of Ariana Grande, George Ezra and Shawn Mendes all securing a place on the main track list.
But Now 100 will also boast a special second disc featuring almost two-dozen hits from down the years, stretching back to the original Now That's What I Call Music back in 1983.
So which songs do the Now team consider fitting of being part of such a momentous release?
Sky News has selected a dozen of those to have made the cut - and you can vote for your favourite, too.