M&S has already outlined plans to close 100 stores by 2022 as it hopes to move at least a third of its clothing and homes sales online.
Of these, 30 have already closed and 25 have been announced including Tuesday's list.
The latest 17 stores to close are: Ashford, Barrow, Bedford, Boston, Buxton, Cwmbran, Deal, Felixstowe, Huddersfield, Hull, Junction One Antrim Outlet, Luton Arndale, Newark, Northwich, Rotherham, Sutton Coldfield and Weston Super Mare.
Sacha Berendji, retail, operations and property director at Marks & Spencer, said: "We're continuing to transform M& S with pace and as part of this we are making good progress with our plans to close over 100 stores - radically reshaping our store estate to become more relevant for our customers.
"Proposing to close stores is never easy, for our colleagues, customers or the local community, but it is vital for the future of M&S. Where we have closed stores, we are continuing to see an encouraging number of customers choosing other nearby locations and shopping on M&S.com."