Marble Bone Disease is a more malignant variant of Osteopetrosis, a congenital skeletal disorder which affects 1 in every 200,000 individuals.
Marble Bone Disease can cause short stature, cerebral calcification and mental retardation.
Osteopetrosis happens when the patient's osteoclasts, a type of bone cells, fail to resorb immature bone.
It results in abnormal bone marrow cavity formation and bone marrow failure.
The disease is usually diagnosed shortly after birth and the patient's life span is usually two years.