Sam Allardyce is set to remain on Merseyside and miss what would be just his second match as Everton manager on Thursday.
The 63-year-old was only appointed last week but, in an unusual twist, he will not be on the trip to Cyprus for Everton's final Europa League fixture against Apollon Limassol.
Allardyce has a long-standing medical appointment - which he made the club aware of when he was in talks to succeed Ronald Koeman last month - and cannot travel.
It is expected that Craig Shakespeare, one of Everton's new assistant manager, will take Allardyce's place in the dugout and lead the team along with long-serving coach Duncan Ferguson.
Everton fly out on Wednesday and will spend two nights in Nicosia before returning to Merseyside on Friday.
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The only thing riding on the outcome of the contest is which of the two teams finishes bottom of Group E - Everton, who have take just one point from a possible 15, need a victory to avoid the ignominy of taking the wooden spoon.
However, Allardyce made it clear at the weekend that he was not placing any stock on the fixture given its proximity to the Merseyside derby.
Allardyce has arrived at a club with a huge injury list and, for that reason, he will send a hugely inexperienced squad to Limassol featuring several academy players.
He made it clear that it would negligible - given that nine first-team squad members are unavailable - to risk any taking too many senior professionals on the trip and jeopardise their hopes of success at Anfield.
Everton have not won at the home of their most bitter rivals since September 1999 and Allardyce, who is aware of the need to get his reign off to a fast start, wants all of his big guns available for the trip.