People over 75 taking daily aspirin after a stroke or heart attack are at higher risk of major - and sometimes fatal - stomach bleeds than previously thought, research in the Lancet shows.
Scientists say that, to reduce these risks, older people should also take stomach-protecting PPI pills.
But they insist aspirin has important benefits - such as preventing heart attacks - that outweigh the risks.
Anyone with concerns should speak to a doctor before considering changing medication, they say.
Doctors generally prescribe daily aspirin for life after a person has a stroke or heart attack to help prevent more attacks.
But researchers have known for some time that aspirin can increase the risk of stomach bleeds.
Until now, most research involved people under 75, showing that the risk of serious bleeds was low in this group.
But with around half the people on lifelong aspirin in the UK now over 75, researchers at Oxford University decided to find out whether the benefits still outweigh the risks in this group.
Their study followed 3,166 patients who had previously had a stroke or heart attack and were prescribed aspirin or similar blood-thinning drugs.
They found that, for patients aged under 65, the annual rate of disabling or fatal bleeds was less than 0.5% (around one person in every 200 people taking the medication).
Meanwhile, for people aged 75 to 84, this rose to three people having major bleeds in every 200.
And the risks of fatal or disabling bleeds continued to increase with age.
Lead researcher Prof Peter Rothwell said: "Our new study gives us a much clearer understanding of the size of the increased risk and the severity and consequences of bleeds in over-75s.
"Our findings raise questions about the balance of risk and benefit of long-term daily aspirin use in people aged 75 or over if a PPI drug is not co-prescribed."
Dr Tim Chico, heart specialist at the University of Sheffield, described the work as a well-conducted study.
He said: "Although bleeding is a well-recognised side-effect of aspirin, this drug is still seen by many people as harmless, perhaps because of how easily it can be bought over the counter."
Meanwhile, GP leader Prof Helen Stokes-Lampard, said: "The study does reassure us that, in most cases, aspirin is still the most appropriate course of treatment for patients, but highlights the importance of managing its use carefully and effectively and that some patients may require additional medication to protect them."
But she added: "It is helpful that the researchers suggest action to mitigate this risk - the prescription of a PPI as a secondary drug - but this does raise a number of health implications.
"It will continue to be necessary to make decisions on a case-by-case basis, considering the patient's unique circumstances and medical history."
Current guidelines in the UK recommend people at "high risk" are given a PPI (proton pump inhibitor) drug which protects the stomach, along with aspirin therapy.
But who exactly is at high risk is not specified. And Prof Rothwell says the majority of over-75s are not prescribed the drug.
Prof Helen Stokes-Lampard, head of the Royal College of GPs, says: "Patients who regularly take aspirin either as prescribed by their doctor or self-medicated, should not panic as a result of this research.
"But if they are concerned about taking the drug regularly, over a long period of time, they should make a non-urgent appointment with their GP, or discuss this with their local pharmacist."
Stopping aspirin suddenly has been shown to have a rebound effect - increasing the chance of heart attack, TIA and stroke for weeks after the pill is stopped.
Anyone who is concerned must discuss it with their doctor. If stopping is advised, doctors will discuss cutting down pills gradually.
For this group a number of previous studies show that the risk of major bleeding is low. Prof Rothwell says he would not recommend a stomach-protecting drug for people of this age.
But researchers recommend anyone taking the drug should review the decision with their doctor every three to five years, to make sure individual circumstances are taken into account.
Researchers say the decision for a healthy individual to take aspirin must be considered very carefully and the benefits and risks to the individual must be discussed with a doctor.
Dr Tim Chico added: "I would strongly recommend that people who are considering taking aspirin to prevent potential future problems such as cancer or heart attack (but who have not had a stroke or heart attack) should discuss this with their doctor."
All drugs have risks and benefits and the decision to take them must be made after weighing these up for the individual. When it comes to PPIs the side-effects can include flatulence, bloating and sometimes stomach infections.